Figure 1. Major pathways of adrenal steroid biosynthesis affected by cortisol-synthesis inhibitors. A=cholesterol side-chain cleavage (3beta-hydroxydehydrogenase and delta-5, delta-4-isomerase); B=17-hydroxylase; C=17,20-lyase; D=11beta-hydroxylase. Adapted from CNS Drugs (1996, 5:311-320), Copyright © 1996, ADIS International.^[92]